The REUSEFUL project promotes biodiversity protection and pollution reduction in South Adriatic coastal areas by advancing circular economy practices. It aligns with EU goals to cut waste by 55% by 2025, establishing reuse centers where furniture, electronics, and clothing are collected, repaired, and redistributed. This initiative reduces waste, supports low-income groups, and fosters environmental sustainability. Key outputs include a Joint Zero Waste Strategy, training, and a scalable cross-border approach for municipalities, benefiting local communities and ecosystems.